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Reference Number EP/Z53464X/1
Title Living-Light: Single Fluorescent Protein based Compact Low-Threshold Bio-Lasers
Status Started
Energy Categories Not Energy Related 95%;
Energy Efficiency (Industry) 5%;
Research Types Basic and strategic applied research 100%
Science and Technology Fields BIOLOGICAL AND AGRICULTURAL SCIENCES (Biological Sciences) 60%;
PHYSICAL SCIENCES AND MATHEMATICS (Physics) 40%;
UKERC Cross Cutting Characterisation Not Cross-cutting 100%
Principal Investigator Dr T Farrow
University of Oxford
Award Type Standard
Funding Source EPSRC
Start Date 01 August 2024
End Date 31 July 2026
Duration 24 months
Total Grant Value £192,297
Industrial Sectors Unknown
Region South East
Programme UKRI MSCA
 
Investigators Principal Investigator Dr T Farrow , University of Oxford
Web Site
Objectives
Abstract Since their inception in 1960, lasers have revolutionized science and technology across data storage, communications, medical applications, and beyond. As biotechnology advances, the need for energy-efficient, biocompatible, and miniaturized devices grows. Integrating biological materials into lasers presents an opportunity to fulfil these demands, enabling biodegradable and compact bio-lasers. Unlike conventional lasers relying on bulky mirrors and cavities, optical cavities can be used to confine light on a submicron scale, achieving strong coupling with biological emitters to create Polaritons (hybrid state of light and matter) which facilitates low-threshold lasing using Polariton Condensation. Recent cavity design innovations, such as curved cavity mirrors and high-reflectivity Distributed Bragg Reflectors, enhance coupling strength and thus efficiency. In this project, I will focus on the development of highly efficient and low-threshold cavity-based compact bio-lasers. Leveraging the advantageous properties of organic materials, particularly large oscillator strength and the ability to activate and excite single fluorescent molecules using Pulsed Activation Localisation Microscopy, I will exploit their single-molecule emission capabilities and adaptability to diverse environments such as in live bacteria to create living-bio-lasers at remarkably low power levels. Ultimately, this project aims to revolutionize bio-lasing technology by creating biocompatible, energy-efficient, and highly sensitive bio-lasers that bridge the realms of biology and photonics at single emitter level, shaping the future of fundamental scientific exploration and technological innovation
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Added to Database 02/07/25