Projects
Projects: Projects for Investigator |
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| Reference Number | BB/J010294/1 | |
| Title | Modular design of a bioinspired tandem cell for direct solar-to-fuel conversion (Solarfueltandem) | |
| Status | Completed | |
| Energy Categories | Renewable Energy Sources(Solar Energy) 50%; Renewable Energy Sources(Bio-Energy) 50%; |
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| Research Types | Basic and strategic applied research 100% | |
| Science and Technology Fields | BIOLOGICAL AND AGRICULTURAL SCIENCES (Biological Sciences) 100% | |
| UKERC Cross Cutting Characterisation | Not Cross-cutting 100% | |
| Principal Investigator |
Professor J Barber No email address given Biological Sciences Imperial College London |
|
| Award Type | Research Grant | |
| Funding Source | BBSRC | |
| Start Date | 04 January 2012 | |
| End Date | 03 July 2013 | |
| Duration | 18 months | |
| Total Grant Value | £175,476 | |
| Industrial Sectors | Transport Systems and Vehicles | |
| Region | London | |
| Programme | International Scheme | |
| Investigators | Principal Investigator | Professor J Barber , Biological Sciences, Imperial College London (99.999%) |
| Other Investigator | Dr J (James ) Murray , Life Sciences - Biology, Imperial College London (0.001%) |
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| Web Site | ||
| Objectives | The main direct beneficiaries of knowledge arising from this grant are anticipated to be academics involved in protein design and artificial photosynthesis, who will benefit from the techniques developed. In addition to our peer-reviewed scientific outputs, we are committed to the broader dissemination of our research to the wider community. Because of the nature of the research, there are likely to be few immediate impacts outside the academic field during the course of this project. However the longer term biotechnological applications could be significant, as apart from the initial proteins made, the project is an enabling technology for future work. | |
| Abstract | All fossil fuels are derived from sunlight via photosynthesis. To cope with the finite supply of fossil fuels, humanity must also learn to use sunlight to generate fuel. In nature photosystem II uses sunlight to oxidise water to oxygen, and equivalents of hydrogen, which are used to reduce CO2 to organic sugars. This difficult oxidation reaction takes place at an unusual CaMn4 metallocluster in the PSII complex, called the oxygen evolving centre (OEC).We propose to mimic the assembly of the OEC in another scaffold protein, by introducing variations in the side chains that will allow a metal cluster to bind. Assembling an OEC in a suitable smart matrix that can deal appropriately with the protons generated by water oxidation, is a crucial prerequisite to building an artificial photosynthetic system. The matrix protects the catalytic cluster from bulk solvent, controls the precise environment of the cluster, and rapidly shuttles protons from the cluster to the solvent. Preliminary scaffold designs have been made using an in-house computer program, SITEGRAFT, which searches for mutations around a site that will generate a target constellation of amino acid functional group positions. This program could also be applied to other active-site design problems. We plan on using four-helix bundle di-iron carboxylate proteins as scaffolds, as these already have a buried dimetal centre, and so should need only minor changes to accommodate a slightly larger cluster. The cluster can be assembled with chemical oxidation, and coupled to light-harvesting pigments with a charge separation motif incorporated to generate a hole with sufficient redox potential (artificial reaction centre) to drive water oxidation. Suitable pigments include zinc-porphyrins, and ruthenium bypyridine complexes. As well as this top-down approach, we will also investigate the incorporation of an OEC-like cluster into smaller protein maquettes, which are simpler than model proteins | |
| Publications | (none) |
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| Final Report | (none) |
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| Added to Database | 22/11/13 | |
