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Reference Number EP/Z531200/1
Title Pushing the Limits of High-Field Solid-State NMR Technology: Enhancing Applications to Advanced Materials, the Life Sciences and Pharmaceuticals
Status Funded
Energy Categories Not Energy Related 70%;
Other Power and Storage Technologies (Energy storage) 5%;
Other Cross-Cutting Technologies or Research (Other Supporting Data) 25%;
Research Types Basic and strategic applied research 100%
Science and Technology Fields BIOLOGICAL AND AGRICULTURAL SCIENCES (Biological Sciences) 25%;
PHYSICAL SCIENCES AND MATHEMATICS (Chemistry) 75%;
UKERC Cross Cutting Characterisation Not Cross-cutting 100%
Principal Investigator Professor SP Brown
No email address given
Physics
University of Warwick
Award Type Standard
Funding Source EPSRC
Start Date 01 August 2024
End Date 31 July 2027
Duration 36 months
Total Grant Value £846,495
Industrial Sectors No relevance to Underpinning Sectors
Region West Midlands
Programme International Centre to Centre
 
Investigators Principal Investigator Professor SP Brown , Physics, University of Warwick (99.991%)
  Other Investigator Professor SEM Ashbrook , Chemistry, University of St Andrews (0.001%)
Professor F Blanc , Chemistry, University of Liverpool (0.001%)
Professor T Carlomagno , Sch of Biosciences, University of Birmingham (0.001%)
Dr T Franks , Physics, University of Warwick (0.001%)
Dr J Griffin , Chemistry, Lancaster University (0.001%)
Dr D Iuga , Physics, University of Warwick (0.001%)
Professor JR Lewandowski , Chemistry, University of Warwick (0.001%)
Mr C Whitewood , Physics, University of Warwick (0.001%)
Dr PTF Williamson , Sch of Biological Science, University of Southampton (0.001%)
  Industrial Collaborator Project Contact , Johnson Matthey plc (0.000%)
Project Contact , Astra Zeneca (0.000%)
Project Contact , Ohio State University, USA (0.000%)
Project Contact , Bruker BioSpin GmbH, Germany (0.000%)
Project Contact , Merck Sharpe And Dohme (0.000%)
Project Contact , Merck and Co Inc, USA (0.000%)
Project Contact , ETH Zurich, Switzerland (0.000%)
Project Contact , Forschungszentrum Jülich (Germany) (0.000%)
Project Contact , Utrecht University (UU), The Netherlands (0.000%)
Project Contact , Pfizer Global Manufacturing, USA (0.000%)
Project Contact , Bristol Myers Squibb (0.000%)
Project Contact , Le Centre national de la recherche scientifique (CNRS), France (0.000%)
Project Contact , National High Magnetic Field Laboratory (MAGLAB), USA (0.000%)
Project Contact , University of Wisconsin - Madison, USA (0.000%)
Project Contact , Goethe University of Frankfurt am Main (0.000%)
Project Contact , Leibniz Inst. for Molecular Pharmacology (0.000%)
Project Contact , Quotient Sciences Limited (UK) (0.000%)
Project Contact , Technical University of Munich (0.000%)
Project Contact , Umea University (0.000%)
Project Contact , University of Bayreuth (0.000%)
Project Contact , University of Florence (0.000%)
Project Contact , University of Lille (0.000%)
Web Site
Objectives
Abstract Solid-state nuclear magnetic resonance (NMR) spectroscopy is arguably the most powerful technology for providing atomic-level structure and dynamics understanding of molecules and materials. The physical and life sciences communities exploit this analytical science technique extensively to address challenging issues in a wide range of systems relevant to, for example, pharmaceuticals, battery materials, catalysis and protein complexes. Importantly, the advances enabled by solid-state NMR as an analytical technique are continually increasing in line with technological progress in the development of new NMR hardware. In particular, the recent development of commercial 1.2 GHz NMR systems stands to open up exciting new directions in NMR methodological development and deliver unprecedented levels of structural, dynamic and mechanistic information. Seven 1.2 GHz NMR systems are already in operation across Europe with further systems soon to be installed in Germany and the USA. UKRI has recently invested in two such systems at the High-Field Solid-State NMR National Research Facility (NRF) at the University of Warwick, and at the Henry Wellcome Building for Biomolecular NMR Spectroscopy at the University of Birmingham. These systems are expected to be operational in the UK in 2025.The proposed project aims to optimise UKRI's substantial investment in high-field solid-state NMR spectroscopy (notably £23M in 1.2 GHz NMR) by working in partnership with fifteen internationally leading laboratories and seven industry partners. The work will focus on sharing technical and application know-how and expertise to deliver new experimental NMR methodologies and protocols, as well as new scientific insight into complex chemical systems. The project will be divided across three main classes of systems: inorganic materials, biosolids and pharmaceuticals, with researchers working in each of these fields. New experimental methodologies will be designed and investigated within the NRF itself, and also exploiting the wide range of NMR hardware and expertise available in the co-investigator team and partner institutions. As well as the main focus of ultra-high field NMR, the NRF and partner institutions will provide access to specialist NMR hardware such as very high- and low-temperature apparatus (100 - 1000 K) to enable complex structural and dynamic phenomena to be probed in greater detail. The techniques developed within the project will enable the capabilities of ultra-high field NMR to be fully realised and will lead to new atomic-level insights into systems of relevance to the wider scientific community and industrial partners. The dissemination of the research and the interaction with international academic and industry partners will help to maintain the UK's position as a world leader in solid-state NMR research
Publications (none)
Final Report (none)
Added to Database 08/05/24